(14 reviews)

510,00 $9800,00 $

Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines

SKU: N/A Category:

Product Description

The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available.

An in-house smoking device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity.

For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent.

This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Additional information


100 g, 200 g, 300 g, 500 g, 1000 g, 2000 g, 5000 g, 10000 g

14 reviews for 5C-AKB48

  1. Eddie L. Rosas

    prices are great, delivery good.

  2. Willie T. Browne

    Price is very good lower than its compete merchant , only thing you can do better is expedite of process of shipping.

  3. Randell C. Harris

    Good service. Received meds in a timely manner. Agent pleasant & patient. all questions answered to my satisfaction.

  4. Bryan S. Rosa

    I have only one comment they are ever thing they say About what they will do for you. Excellent

  5. Charles L. Bowles

    So nice to get our products by mail at very reasonable prices!

  6. Sidney B. Lewis

    always fair prices and helpful contacts. Would recommend them to all.

  7. Leonard S. Plummer

    Great service recommended to many

  8. John T. Stewart

    excellent service at a reasonable price….

  9. Jeffery K. Perry

    I’m totally satisfied with the way they handled my prescription. The customer service is very efficient. Congratulations.

  10. Joey J. Solomon

    Reliable, good delivery, fair prices. All pharmacies should be like this.

  11. Lewis B. Lockhart

    Excellent service and very helpful staff.

  12. Donald T. Cooney

    Very impressed extremely fast delivery will definitely use again

  13. David H. Cobb


  14. Jose S. Budd

    Superb service and pricing, been using for many years now——highly recommend!

Add a review

Your email address will not be published. Required fields are marked *

has been added to the cart. View Cart

You cannot copy content of this page