(15 reviews)

280,00 $6000,00 $

5F-ADB is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug. 5F-ADB is a potent agonist of the CB₁ receptor, though it is unclear whether it is selective for this target.

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Product Description

N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine methyl ester (5F-ADB) is one of the most potent synthetic cannabinoids and elicits severe psychotic symptoms in humans, sometimes causing death. To investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5F-ADB on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. 5F-ADB-induced changes in spontaneous firing activity of dopaminergic and serotonergic neurons were recorded by ex vivo electrophysiological techniques. In dopaminergic neurons, 5F-ADB (1 μM) significantly increased the spontaneous firing rate, while 5F-ADB failed to activate dopaminergic neurons in the presence of the CB1 antagonist AM251 (1 μM). However, the same concentration of 5F-ADB did not affect serotonergic-neuron activity. These results suggest that 5F-ADB activates local CB1 receptors and potentiates midbrain dopaminergic systems with no direct effects on midbrain serotonergic systems.

Additional information


50 g, 100 g, 200 g, 300 g, 500 g, 1000 g, 2000 g, 5000 g, 10000 g

15 reviews for 5F-ADB

  1. George L. Zook

    Customer service is professional, helpful, and patient. Thank you, especially Suzanne.

  2. Bobby F. Parker

    Quick and easy

  3. David I. Clark

    Absolutely love the ease and efficiency of the pharmacy. It has also been the cheapest pharmacy for my script thus far.

  4. Michael L. Wilson

    Very happy so far.

  5. Jose F. Pratt


  6. Timothy M. McDonald

    My pill in the USA is over $5.00 each. Here, just over .50 cents a pill. Delivery is quick. I love this company!

  7. Michael D. Quiroz

    Efficient ordering, courteous price checks, good prices and helpful record keeping. Very satisfied with their service.

  8. Robert N. Young

    Excellent accommodating service-always very professional

  9. Bryan E. Perez

    Customer service was great. My transaction went smoothly. Will use again.

  10. Mark P. Watson

    Excellent services

  11. Earl A. Baier

    I placed part of my original order and I received it fast. I like the service you have given me. thank you

  12. David I. Clark

    First rate service and decent pricing. The drugs always arrive before the date quoted, never late.

  13. Louis L. Walton

    very long term customer….overall service is very good

  14. Harold J. Fulton

    It’s a pleasure to be doing business with

  15. Christopher E. Apperson

    Support representative – very patient and knowledgeable. Very helpful with the ordering process and applying discounts.

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